- email: Jason.Pomerantz@ucsfmedctr.org
- office phone: 415-353-4285
- campus address: 505 Parnassus Avenue, M-593
- box: 0932
My research interests are in mesenchymal tissue regeneration. Our lab is taking broadly based molecular, cellular, organismal and evolutionary approaches to study skeletal and cardiac muscle regeneration and to understand how different regenerative capacities arose among species. The ultimate practical goal of our research is to develop novel approaches to repair and regenerate tissues that will have a positive impact on the treatment of a range of human diseases such as muscle loss after trauma and cardiac dysfunction after infarction. We are using the mouse, zebrafish and axolotl as model organisms. In regenerative organisms such as the zebrafish and axolotl, evidence suggests that apart from classical tissue stem cells, regeneration can occur by an alternative mechanism whereby post-mitotic differentiated cells reenter the cell cycle, proliferate and give rise to the regenerate. The existence of such a mechanism may underlie the extraordinary ability of these animals to regenerate body parts, including the heart. By focusing on differences in the maintenance of the post-mitotic state, we are developing models of regeneration in mice where regulation mimics the scenario in regenerative organisms.
As a clinician, Dr. Pomerantz is a plastic surgeon who specializes in pediatric plastic and reconstructive surgery including the treatment of craniofacial anomalies. He cares for children and adults with congenital or acquired deformities, especially of the head and face, such as cleft lip and palate, craniosynostosis and traumatic facial injuries.
Pomerantz JH*, Mukherjee S, Palermo A, Blau HM. Reprogramming to a muscle fate by fusion recapitulates muscle differentiation. Journal of Cell Science 122(7): 1045-1053, 2009.
Zhang F*, Pomerantz JH*1, Sen G, Palermo AT, Blau HM1. Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons. Proceedings of the National Academy of Sciences USA, 104(11): 4395-4000, 2007.
Pomerantz J, Schreiber-Agus, N, Liegeois, NJ, Silverman, A, Alland, L, Chin, L, Potes, J, Orlow, I, Lee, HW, Cordon-Cardo C, and DePinho RA. The INK4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2’s inhibition of p53. Cell, 92: 713-723, 1998.
Chin L *, Pomerantz J*, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C., Horner JW, and DePinho RA. Cooperative effects of INK4a and RAS in melanoma susceptibility in vivo. Genes & Development, 11: 2822-2834, 1997.