Edward Hsiao MD, PhD
- Email: edward.hsiao@ucsf.edu
- Office phone: (415) 476-9732
- Campus address: 513 Parnassus Ave., S965
- Box: 0794
Edward Hsiao, MD, PhD, is an endocrinologist at the University of California, San Francisco.
Dr. Hsiao’s research focuses on understanding how hormone signals affect mesenchymal tissues in normal growth and in disease. His recent projects focus on the skeletal system, and include developing a new mouse model for studying G-protein signaling in bone growth, creating new methods for identifying embryonic stem (ES) cell-derived tissues, and developing human induced pluripotent stem cell (iPSC) and ES cell models from patients with genetic bone diseases. By using a wide spectrum of approaches, he hopes to develop a broader understanding of the biology underlying skeletal development, develop new models for studying pathologic calcification, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect other mesenchymal tissues such as fat, muscle, cartilage, and blood vessels.
Dr. Hsiao received his BA magna cum laude in biochemistry and molecular biology from Harvard College. Dr. Hsiao completed his MD and PhD at the Johns Hopkins Medical School. After completing his internal medicine residency at Johns Hopkins, Dr. Hsiao came to the UCSF for an endocrinology fellowship. He is currently an adjunct assistant professor in the Division of Endocrinology and Metabolism at UCSF, working with Drs. Bruce Conklin at the Gladstone Institute of Cardiovascular Disease and Robert Nissenson at the San Francisco VA Medical Center. Dr. Hsiao is a former California Institute of Regenerative Medicine Clinical Scholar at the Gladstone Institute of Cardiovascular Disease, and is the recipient of a 2007 Young Investigator Award from the American Society for Bone and Mineral Research, a 2008 Sandler Postdoctoral Research Fellowship Award, a 2008 National Osteoporosis Foundation research grant award, and a NIH K08 Physician Scientist Career Development Award.
Hsiao, E.C., Boudignon, B.M., Chang, W.C., Bencsik, M., Peng, J., Nguyen, T.D., Manalac, C., Halloran, B.P., Conklin, B.R., and Nissenson, R.A. (2008). Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105(4), 1209-1214. PMCID: PMC2234117.
Ivey, K.N., Muth, A., J., A., King, F.W., Yeh, R.-F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., and Srivastava, D. (2008). MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2(3), 219-229. PMCID: PMC2293325.
Conklin, B.R., Hsiao, E.C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J.R., Guettier, J.M., Chang, W.C., Pei, Y., McCarthy, K.D., Nissenson, R.A., Wess, J., Bockaert, J., and Roth, B.L. (2008). Engineering GPCR signaling pathways with RASSLs. Nat Methods 5(8), 673-678. PMCID: PMC2703467.
Hsiao, E.C., Yoshinaga, Y., Nguyen, T.D., Musone, S.L., Kim, J., Swinton, P., Espineda, I., Manalac, C., DeJong, P., and Conklin, B.R. (2008). Marking embryonic stem cells using a 2A self-cleaving peptide: A NKX2-5 Emerald GFP BAC reporter. PLoS One 3(7), e2532. PMCID: PMC2430532.
Hsiao, E.C.*, Millard, S.M.*, Louie, A., Huang, Y., Conklin, B.R., and Nissenson, R.A. (2010). Ligand-mediated activation of an engineered Gs G-protein coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinology. 24(3), 621-631. PMCID: PMC2840804.
Hsiao, E.C., Boudignon, B.M., Halloran, B.P., Nissenson, R.A., Conklin, B.R. (2010). Gs G-protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 25(3): 584-593. PMID: 20200944.
van Laake, L.W., Qian, L., Cheng, P., Huang, Y., Hsiao, E.C., Conklin, B.R., and Srivastava D. (2010). Reporter-Based Isolation of Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Cardiac Progenitors Reveals Limited Gene Expression Variance. Circulation Res. 107: 340-347. PMCID: PMC2919280.
Hsiao, E.C., Nguyen, T.D., Ng, J.K., Scott, M.J., Chang, W.C., Zahed, H., and Conklin, B.R. (2011). Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice. Stem Cell Research and Therapy 2(2), 11. PMCID: In process.
Kazakia, G.K., Speer, D., Shanbhag, S., Majumdar, S., Conklin, B.R., Nissenson, R.A., and Hsiao, E.C. (2011). Mineral Composition Is Altered by Osteoblast Expression of an Engineered Gs-Coupled Receptor. Calcified Tissue International 89: 10-20. PMCID: In process.
For more information, please visit the Hsiao Lab website
